15 million yen

31 (as of September 2003)

770 million yen

We contribute to keep someone in good health through custom manufacturing of bulk pharmaceutical and pharmaceutical intermediates.

The company, originally founded as chemical manufacturer, has built its operating base on synthesis technologies. Under the quality control system that meet GMP standard, we manufacture bulk pharmaceutical, pharmaceutical intermediates and investigational new drugs. Custom manufacturing of general chemical products is also available.

*Custom manufacturing of bulk pharmaceutical and pharmaceutical intermediates
The bulk pharmaceutical and pharmaceutical intermediates manufactured under the advanced product management system that meet GMP standard always received high evaluation from our customers and they have high level of confidence in our ability to provide high quality products. In order to meet diversity of demands from our customers, we will continue to work hard to improve our product management system.

*Custom manufacturing of investigative new drugs and prototypes
We support our customers’ clinical trial in overseas by using our accumulated experiences of IND manufacture. We will also propose the best synthetic method for each process from R&D to mass production.

We are always ready to meet your requests with wide range of synthesis technologies we have accumulated over the years of experience in custom manufacturing  and research.

Acylation reaction, synthesis of amino compound, Wolff-Kishner reduction, esterification reaction, reduction reaction, grignard reaction, Schotten-Baumann reaction,  thiolate reaction, halogenation reaction, synthesis of heterocyclic compound, Friedel-Crafts reaction, optical resolution, Leuckart reaction, high temperature reaction (to 300 C degree), low temperature reaction (to minus 80 C degree), column separation and other organic synthesis reactions

New Research and development wing (Kilo-lab) has been completed

We installed kilo-lab ultra-low temperature reactor (reaction temperature of minus 150 C degree to minus 80 C degree) of 30 litters capacity.

We will welcome your order for hit compounds and lead compounds that are vital for pharmaceutical research.

The new plant exclusively used for IND is completed.

We can handle the reaction temperature of minus 80 C degree to 270 C degree with reactor capable of handling 300 litters to 1000 litters and we also have facilities for column purification and autoclave with production control system meeting cGMP requirement.
*Specification of new plant

Plant facilities
Flexible system of production from high-mix low-volume manufacture to mass production

300L ultra-low temperature reactor

Reactor : 50 to 5000L (GL, SUS, Hastelloy)
Distillation apparatus : 100 to 3000L (GL, SUS)
Autoclave : 100L（SUS）
Extraction filter : pressure filtration unit, vacuum filtration unit, centrifugal separators
Dryer:decompression dryers, vibro fluid bed dryers (SUS)

1,000L GL reactor

Analytical Instrument
State-of-art analytical instrument guarantees to provide you our high quality products and services.

High-speed liquid chromatography
gas chromatography
Infrared spectrophotometer
Ultraviolet and visible ray spectrophotometer
Polarimeter
Karl-Fischer titrator
potentiometrical titrator
Melting point apparatus
electric balance

Our quality control system meets the worldwide standard.

We meet the requirement of both domestic and international GMP standard such as FDA inspection not only for our final products but also for each step of their manufacturing process including synthesis in order to build global standard quality control system to live up to our customers expectation.

* DMF submitted
* EDQM submitted
* FDA inspection, inspected by Pharmaceutical Division Department of Health and Social Services, number of past record of inspection by our users

Custom manufacturing at oversea site is available (Business partner in China and India)

Small scale production | Oxidation, Heavy metal compound | Oxidation, Peroxide | Rectification | No-pressure distillation | Vacuum distillation | Hydrogeneration | Reduction, Na/Li | Reduction, Catalytic | Low temperature reaction (over -20 C degree) | High temperature reaction (over 200 C degree) | Extraction | Optical resolution | Recrystallization | Drying, (No-pressure/Vacuum) | Filtration | Crystallization | Column purification | Dehalogenation | Nitration | Amination | Acylation | Esterification | Diazotization | Sulfonation | Formylation | Carbonylation | Racemization | Acid chlorides | Acid amide | Organic lithium | Grignard reaction | Friedel-Crafts reaction | Oganic sulfur compound | Optical resolution | Phosphoric compound | Production of pharmaceuticals/cosmetics | Wolff-Kishner-reduction | Gas absorption | Fine Grinding ( <1000μm->=10μm ) | Leuckart reaction | Liquid chromatography analysis（LC） | Gas chromatography analysis | Thin layer chromatograph(TLC) | Karl Fischer moisture analysis | Specific gravity | Optical rotation | Flexibility | Fusing point | Coagyulation point | Head Space Gas Chromatography(HS/GC) | Halogenate, Diverse halogenating agents | Halogenate, Thionyl chloride, Sulfuryl chloride etc | Hydrogen cyanide, Sodium cyanide, Potassium cyanide | Mercaptan | Reduction, Nitro compound | Diazo-coupling reaction | Chlorosulfonation | Sulfonamidation | Chiral compound | Azidation | Potentiometric titration |