SUGAI CHEMICAL INDUSTRY CO.,LTD.

Paid-in Capital

2510 million yen

Number of Employees

179 (as of March 31 2022)

Main Products

CAS.NO.Index

Formula Index

Facilities and Equipments

Wakayama Site

Fukui Site

Manufacture's Feature


We aim to unlock greater growth together with our stakeholders as a fine chemical company that speeds up the evolution of industries.
Osamu Noma,President Since our founding in 1928, Sugai Chemical has built up our own proprietary organic synthesis and production technologies through a great deal of trial, error and progress for close to a century. Today, we have established “one product, one customer” model of contract manufacturing to satisfy requirements of our customers. This enables us to supply a broad range of products to customers around the world, such as intermediates for pharmaceuticals, agrochemicals and functional materials, along with surfactants. In recent years, we are focusing also on the development of our original products in response to more sophisticated and diverse market need. Moreover, we are dedicating more attention to sustainability initiatives to ensure that that we continue to evolve and grow in a sustainable manner. While circumstances surrounding us change by the minute, we are committed to being a company that brings value to society by understanding and addressing social issues such as digital transformation and climate change. We will fulfill our corporate social responsibilities and achieve our mission of becoming more than just a manufacturer of intermediates, transitioning into a fine chemical company that speeds up the evolution of various industries. I would like to personally thank our stakeholders for your continued support as we move forward.

Specialized Areas

Products for various Industries
Beginning with intermediates for dyes and pigments, we have moved into a number of other fields including pharmaceutical and agrochemicals while expanding our extensive product lineup to include fine chemicals. We also retain much proprietary production technology as well as engage in development and production of products ranging from niche to the ordinary.
Pharmaceutical Intermediates	Our all-round technology of contract manufacturing based on rich experience with organic synthesis, advanced manufacturing technology, and thorough quality control allows us to supply pharmaceutical intermediates to pharmaceutical companies around the world. We contribute to improvement of Quality of Life through the supply of our intermediates in the future too.
Active Ingredients and Intermediates for Agrochemicals	We manufacture active ingredients and intermediates for fungicides, insecticides, and herbicides which are essential to increase agricultural productivity. Our active ingredients and intermediates have a high reputation in Western countries whose environmental criteria is very severe. We contribute to improvement of global food problem through the supply of our products in the future too.
Functional Chemicals	Beginning with monomers for optical and electronic materials with the highest refractive index in the world, our unique products are used for a wide range of fields and industries. In the future, we will challenge development of unique, high value-added products in cutting edge fields.
Surfactants	Industrial surfactants used in various applications such as cleaning, emulsification, liquefaction, disinfection, and electrostatic prevention, are our most important products. Our surfactants are widely used for dispersant of paints, agrochemicals, and ink, and they support our life.
Intermediates for Dyes and Pigments	Intermediates for Dyes and Pigments are the origin of Sugai. Our products with high purity, manufactured by unique organic synthetic technology accumulated for a long period, have a high reputation from customers. Final products manufactured from our dye intermediates are used for a wide range of dyes and colorants for cotton fibers, synthetic fibers, chemical fibers, paper & pulp, leather, hair dye, and cosmetics. Our pigment intermediates are provided as raw materials for printer ink, various paints, and cosmetics.

Specialized Technologies

Proposal of the most Appropriate Process for Customers based on our Diverse Reactive Technologies

Through much results and experience as a custom manufacturer so far, we have been accumulating a great store of divers reactive technologies including oxidation, reduction, Grignard reaction, halogenations, and cyanation reaction which are at the top level among custom manufacturers in Japan. Recently we have been also actively trying to establish new technologies, such as optical resolution, asymmetric synthesis, and flow synthesis. Combination of these wide range of organic synthesis technologies makes it possible to achieve efficient development of target products responding with our customers’ diverse, sophisticated requirement.

主要な反応技術

Acylation

Alkylation

Allylation

Amination

Bromination

Carboxylation

Chlorination

Condensation

Coupling

Cyanation

Esterification

Fluorination

Formylation

Hydroxylation

（Meta）acrylation

Nitration

Oxidation

Optical Resolution

Reduction

Ring formation

Sulfonation and Chlorosulfonation

Examples of Reactions Using the Above Technologies

Synthesis of complex compounds with combination of multiple unit process.

Reaction Example (1):

Naphthalenesulfonic acid → (Chlorination) → naphthalenesulfonyl chloride → (Reduction) → naphthothiol

Reaction Example (2):

Naphthol → (Reduction) → Hydroxy-decahydronaphthalene → (Allylation) → Allyloxy-decahydronaphthalene → (Oxidation) → Glycidyloxy-decahydronaphthalene

Reaction Example (3):

Aniline → (Amidation) → 1-Butyl aminobenzene → (Nitration) → 1-Butylamino-2-nitrobenzene → (Reduction) → 1-Butylamino-2-aniline → (Ring formation) → 2-Propylbenzene imidazole

Reaction Example (4):
2-hydroxy-6-naphthoic acid → (Bucherer reaction) → 2-amino-6-naphthoic acid → (Sandmeyer reaction) → 2-bromo-6-naphthoic acid

Low Temperature Reaction			Possible to react at -10°C as minimum limit of temperature.
Grignard Reaction			We have commercially established Grignard reaction including preparation of Grignard reagent from Mg metal.
Cyanation Reaction			It is possible to provide various cyanide compounds under safe and effective operation including safely handling NaCN and KCN as well as detoxifying system of waste water containing CN-.
Reactions with Metal Sodium			It is possible to use molten metallic sodium safely on industrial scale, as well as to prepare dispersion solution. The reaction with metal sodium is available for condensation and reduction.
Reduction			Reduction is one of our best unit process. In particular, we have much results and experience of catalytic hydrogenation which is not harmful to the environment.
Halogenations			It is possible to provide various halogenated compounds based on technologies commercially established for chlorination, bromination, iodination, and fluorination.

R&D

Overall support from research and development stage through commercial production
Provision of our overall support from research and development stage through commercial production that helps customers’ development with high reliability. In the research and development stage, we closely examine customers’ needs through market research, and then it promotes the development and production of original products.
Research and Development Stage	1. Literature research We conduct literature research to propose the best possible synthetic method and process, even when only the target compound is indicated without the synthetic information. 2. Laboratory research We optimize synthetic process through laboratory research to address customers’ requirement accurately. We propose appropriate solution to problems identified during lab experiments based on our extensive know-how of organic synthesis. Additionally, we proactively share information with regard to the status of laboratory research, and provide support of customer’s development collaboratively.
Scale-up Stage	3. Kilo lab We are fully capable of scale-up production requiring kilogram scale of material by appropriate equipment such as up to 50 L reactor vessels, 300 mm diameter Nutsche funnel, and 10 L SUS press filter. 4. Pilot plant We conduct pilot production on which several kilograms to several dozen kilograms of target material is produced in accordance with the synthetic process established in the laboratory research, and then we optimize the industrial manufacturing process based on results and data of the pilot production. In addition, we also respond to pilot production to provide sample required for customer’s development.
Production Stage	5. Trial production We conduct trial production in commercial plant to check whether there are any problems or scale-up effect. In case we find any problems, we return to the laboratory research to investigate solutions, and then we establish the optimal productive conditions on retrial production.。 6. Commercial production We conduct commercial production (campaign production) according to the productive condition established on trial production. In case of necessity even on commercial production stage, we return to the laboratory research to ensure safe and stable operations. We also work to improve productivity and continued cost reduction.

New Product & Developed Product

Dinaphthothiophene Derivatives	View More
Dinaphthothiphene (DNT) is a compound with a very extremely high refractive index (1.82 at 589nm) as a single organic chemical substance. We meet customers’ requirement by providing various derivatives of DNT with functional groups by our best organic synthesis technologies. Representative derivatives are shown as below.

Naphthothiol Derivatives	View More
Naphthothiol and its derivatives have very refractive index among other organic compounds. In particular, the 1,6-derivative has both high refractive index and good solubility (compatibility), and we can also supply various derivatives with polymerizable groups.

Binaphthol Derivatives	View More
Binaphthol derivatives have high value in use as organic compounds with a high refractive index, and we can supply various derivatives.

Calixarenes	View More
We have two main types of Calixarenes such as S series (n=4,6,8) with sulfonic group and B series (n=4,6,8) with tert-butyl group. Also, we can supply CALXB4-EA that is used for additive of cyanoacrylate adhesive. Development of monomers with polymerizable groups is also expected. Representative derivatives are shown as below.

Decaline Derivatives
We develop 2DH, 2DHA (acrylate), and 27DGDHN (glycidyl ether) have high heat-resistant and transparent property. These Decaline derivatives are expected to be used for optical area.

Specialized Manufacturing Equipment

Diverse facilities
Our manufacturing facilities are multipurpose. We address a broad range of customers’ needs with accuracy, flexibility, and swiftness, including provision of several grams of sample through commercial production of several dozen tons of product.
Laboratory research (30 to 5,000 mL)	Reactor vessels and separatory flasks (30 to 5,000 mL), SUS autoclave (100 to 3,000 mL), Glass-lining autoclave (300 to 1,000 mL), SUS Press filter (200 mL), Glass-lining press filter(1 L), Rectifying column, Thin-film evaporator, Pure water system, Ultrapure water system, Constant temperature and humidity oven, Refrigerant device (minimum -15 ℃), Vacuum dryer, Homogenizer, Light flow synthesizer, Syringe pump, etc.
	Laboratory
Kilo lab (10 to 50 L)	Reactor vessels (10 to 50 L), Mantle heater, Separatory flasks (10 L), SUS Press filters(1.5 to 10 L), Nutsche funnel (300 mm diamete), Glass filter (185 mm diameter), Vessels (up to 100 L), etc.
Pilot plant (50 to 2,000 L)	Fukui Research Institute (pilot plant)
	Inside of Fukui Research Institute (three stories)
Trial production (3,000 to 12,000 L)）
Commercial production (3,000 to 12,000 L)	Reactors
	Thin-film evaporator
Analytical instruments	HPLC, GC, GPC, GC-MS, LC-MS, DSC, TG/DTA, IC, Reaction calorimeter, Atomic absorption spectrophotometer, Combustion ion chromatography, IR moisture meter, Karl Fischer moisture meter, pH meter, B-type viscometer, UV spectrophotometer, IR spectrophotometer, Digital microscope, Automatic titrator, Colorimeter, Turbidity meter, Total organic carbon (TOC) meter, Conductivity meter, Vacuum dryer, Electric furnace, Pure water system, Ultrapure water system, etc.
	HPLC

Qualification for Quality Control

Quality Engagement
We have obtained ISO 9001 certification which is international quality management system for the entire company including research departments, and we have ensured that we are constantly improving quality. Additionally, we conduct thorough quality control on all stage from research and development through commercial production. We not only maintain this high level of quality, but also work toward continuous improvement of quality to take our production technologies to the next level.
Quality Policy	We respond to expectations and needs from customers, and we continue to improve so that we can always provide quality to customers’ gain trust and satisfaction.
ISO 9001 Certification for Quality Management System We have obtained ISO 9001 certification so that we can constantly provide high quality products and service to gain customers’ trust and satisfaction. We will continue efforts to maintain and improve quality through development and manufacture of fine chemicals with high quality in the future too.

Applicable Standard	JIS Q 9001 : 2015（ISO 9001 : 2015）
Registration Date	March 16, 1998
Certification No.	JCQA-0304
Registered Section	Company-wide

Plant Location of Custom Manufacturing

Wakayama Site Wakayama Nishi Factory
1280 Minato, Wakayama, 640-8404 Japan MAP TEL: +81-73-423-6341 FAX: +81-73-423-6345 < By Train > From JR Wakayama station Use bus to reach Minato bus stop 1 minute walk from Minato bus stop < By Car > 25 minutes from Wakayama Interchange 25 minutes from Wakayama Minami (south) Smart Interchange
Fukui Site / Fukui research Institute
29-75-1, Ishibashicho, Fukui, 910-3137 Japan MAP TEL: +81-776-85-1150 FAX: +81-776-85-1101 < By Train > From JR Fukui station Change the train to Echizen-Tetsudo (local line) and get off at Nishinagata-Yurinosato station (E35) Take the dedicated bus service to get to Sugai Chemical directly at Nishinagata-Yurinosato station (Available on weekdays) < By Car > 50 minutes from Fukui Interchange

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