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Fujimoto Chemicals Co., Ltd.

Paid-in Capital

JPY 87400000

Main Products

Main Product 2-amino-pyridine derivative

Main Product 3-amino-pyridine derivative

Facilities and Equipments

List of Equipment (Manufacturing facilities for HPAPI)

List of Equipment Manufacturing facilities for general products


Small scale production / Blending, Subdividing, Filling / Oxidation, Heavy metal compound / No-pressure distillation / Drying, (No-pressure/Vacuum) / Hydrogenation / Bromination / Ullman reaction / Optical microscope / Nuclear magnetic resonance spectrometry(NMR) / Differential scanning calorimetry(DSC) / Liquid chromatography analysis(LC) / Total organic carbon analysis(TOC) / Color difference / Metallic sodium, Metallic potassium / Reduction, Nitro compound / Azidation / Mizoroki-Heck reaction / Kumada-Tamao-Corriu cross coupling / Oxidation, Peroxide / Vacuum distillation / Reduction, Metalic hydride / Low temperature reaction (over -20 C degree) / Photochemical reaction / Chlorination / Nitration / Acylation / Organic lithium / Oganic sulfur compound / Chiral synthesis / Chromatography / Fine Grinding ( <1000μm->=10μm ) / Inductively coupled plasma-atomic emission spectrometry / Scanning electron microscope(SEM) / Electronic microscope / Differential thermal analysis(DTA) / Gas chromatography analysis / Karl Fischer moisture analysis / Specific gravity / Negishi cross coupling / Glaser reaction / Ammoxidation / Reduction, Catalytic / Column purification / Fluorination / Diazotization / Grignard reaction / Optical resolution / Ultrafine Grinding(<10μm) / Inductively coupled plasma-plasma mass spectrometrv(ICP-MS) / Scanning electron microscope(SEM) / Bulk specific gravity / Head Space Gas Chromatography(HS/GC) / Organosilicon compound / Acetalization / Hydrogeneration / Oxidization, Air / Iodination / Acid chlorides / Reaction, NaNH2 / High potency active (HPA) manufacturing / Ultraviolet-Visible spectrophotometer(UV-VIS) / Liquid chromatography analysis-mass spectrometry(LC-MS) / Drying capacity / Thermogravimetric analysis(TG) / Diazo-coupling reaction / Diazocoupling / Sonogashira-Hagihara Cross Coupling / Oxidization, Halogenide / Reaction, NaH / Active sludge process / Suzuki-Miyaura cross coupling / Sandmeyer reaction / Reaction calorimetry / Gas chromatography analysis-mass spectrometry(GC-MS) / Viscosity / Halogenate, Diverse halogenating agents / Amidination / Dehydrogenation / Reduction, High/Middle-pressure / Amination / Sulfonation / Organic sodium / Phosphoric compound / Pollution prevention / Particle size distribution / Halogenate, Thionyl chloride, Sulfuryl chloride etc / Buchwald-Hartwig cross coupling / Oxidation, Swern / Extraction / X-ray diffraction(XRD) / Halogenate, NCS, NBS, NCI etc / Chlorosulfonation / Allylation / Active ingredient for pharmaceutical・cosmetic ingredients / Crystallization / Others, Halogenation / Alkylation / Ion chromatography(IC) / Optical rotation / Sulfonamidation / Chiral compound / Oxidation, Nitric acid / Optical resolution / Aldol reaction / Nitrosation / Coupling reaction / Wittig reaction / Thin layer chromatograph(TLC) / Fusing point / Oxidation, Jones / Reduction, Na/Li / Recrystallization / Esterification / Oppenauer oxidation / Potentiometric titration / Epoxidation / Filtration / Baeyer-Villiger oxidation / Oximation / Carbonylation / Others / Cannizarro reaction / Knoevenagel condensation / Silylation / Diels-Alder / Tishchenko reaction / Perkin reaction / Hydroxyethylation / Hydroxymethylation / Hydroxylation / Vilsmeier reaction / Fries rearrangement / Friedel-Crafts reaction / Hoesch reaction / Hofmann's Reaction / Formylation / Michael addition / Mannich reaction / Methylolation / Racemization / Leuckart reaction / Cyclization / Ring-Opening reaction / Dealkylation / Dehalogenation / Dehydration / Rearrangement / Acid amide / Decarbonation / Quaternarization of Amine, Benzyl oxide /

Manufacture's Feature

 We offer “One-Stop Solution” from market and scientific research, R&D to manufacturing in three core businesses: pharmaceuticals, cosmetics, and chemical products.
  • Process Development
    • We offer a wide range of process development service from manufacturing methods that can be scaled up to industrial level of manufacturing method, based on the technology we have accumulated over many years in the contract manufacturing of APIs and intermediates.
  • Testing Methods Development
    • We are capable of developing testing methods for various stages from the initial development to the commercial production.
  • Special Technology
    • Although we already have various skills and technologies accumulated in years of experiences of manufacturing APIs and intermediates, we are striving to build technologies to introduce new synthesis technologies without being satisfied with the status quo. In the field of special synthesis technologies, industrial-scale production is available. We developed and commercialized the following special synthesis technologies.
  • Nucleotides
    • We synthesize nucleic acid derivatives with various chain lengths from a nucleic acid monomer to an oligomer.
    • 〈Pseudo-liquid support〉
    • Trademark: Fujimat®
  • Contract manufacturing of raw material for cosmetics
  • Powder forming of raw material for cosmetics
 Chemical Products 
  • Contract Manufacturing
    • We will select and propose the most suitable processing manufacturer in Japan or in overseas after strictly scrutinizing quality, price, and manufacturing environment using our cultivated technology. In recent years, we have received inquiries about spray drying, powder processing, hydrothermal reaction, cleaning agents, etc.
  • Trading
    • We trade mainly in the three fields of APIs and intermediates, fine chemicals, and solvents.

Specialized Technologies

  Although we already have various skills and technologies accumulated in years of experiences of manufacturing APIs and intermediates, we are striving to build technologies to introduce new synthesis technologies without being satisfied with the status quo. In the field of special synthesis technologies, industrial-scale production is available.
Carbonylative Cross Coupling
  • The carbonylative cross coupling is an effective method which enables a direct synthesis of amides or esters from halogenated aromatic compounds.
  • We provide the industrial scale manufacturing although it uses harmful carbon monoxide.
Mitsunobu Reaction  
  • The Mitsunobu reaction is an effective method which brings alcohol to an inversion of stereochemistry.
  • This reaction also enables synthesis of phenyl ethers and alkylation of pyrroles.
Low-temperature Reaction
  • We provide low-temperature reactions down to approximately -80°C using n-BuLi or DIBAL-H.
Catalytic Hydrogenation
  • The reaction is used for amine synthesis and debenzylation by reduction of nitro and cyano groups. We can use both of homogeneous catalysts and heterogeneous catalysts such as Pd/C in our manufacturing.
Reaction using Transition Metal Catalysts
  • We have used Pd, Ru, Zn, Cu, W catalysts for the manufacturing.
Other reactions/technologies
  • Halogenation, oxidation, Grignard reaction, coupling, amidation, wittig reaction, Friedel-Crafts reaction, and Crutius rearrangement
  • high-potency active pharmaceutical ingredients manufacturing, API milling, and column purification

Specialized Manufacturing Equipment

These facilities are capable of handling a wide range of GMP-compliant manufacturing processes for active pharmaceutical ingredients and intermediates.
Reactor sizes range from small to large quantities, and we also have special reaction vessels (single-pressure reaction, low-temperature reaction, acid-resistant reaction, etc.), as well as a full lineup of ancillary facilities for post-reaction treatment.

【Features of Kinraku Plant (Amagasaki-City)】
01 Having the laboratory on site, a comprehensive technical support system from lab scale to kilogram scale is available.
02 Close information sharing with a client’s R&D enables a smooth technical transfer to production.
03 We also support the development of analytical methods to speed-up a pharmaceutical development by transferring analytical techniques and analytical validation to our clients.
04 Considering the surrounding environment and the work environment of employees, we built a manufacturing facility for HPAPI with containment design.
05 Various types of mills are available to meet the characteristics of powders. Jet milling with nitrogen gas in a containment environment is also available.
06 We have a low-temperature reactor (SUS) using liquid nitrogen and a Calss-1 pressure reactor made of Hastelloy.

Pilot-scale equipment--- Kinraku Plant, The second plant, Facilities for development-stage production
API equipment--- Kinraku Plant, The second plant, S area
Manufacturing facility for HPAPI--- Kinraku Plant, The second plant,
Facilities for highly potent active pharmaceutical ingredients
Micronizers: Jet mill x 1 and Pin mill x 2

【 Features of Senboku Plant (Izumiotsu-City 】
01 We have facilities suitable for various commercial production from small scale to large quantities.
02 Our manufacturing facilities for HPAPI are among the largest in the world.
03 We have the QC facility dedicated to HPAPI, which minimizes contamination with other chemical substances.

The manufacturing facility for HPAPI---Senboku Plant, The third plant, Facilities for highly potent active pharmaceutical ingredients
Senboku Plant, The fourth plant, Facilities for highly potent active pharmaceutical ingredients
The manufacturing facility for API---Senboku Plant, The third plant
The manufacturing facility for intermediates---Senboku Plant, The first and the second plant
Micronizers: Jet Mill x 2, Counter jet mill x 1, Pin mill x 1, and Power mill x 1

Manufacturing facility Analysis laboratory
Isolator Senboku Plant, The fourth plant

Qualification for Quality Control

Based on c-GMP, we have established a highly productive and reliable quality assurance system.
  • We have established a quality control system and manufacturing management system based on the latest GMP to guarantee quality.
  • We have also invested in the systems and improved SOPs to secure data integrity (DI) based on the ALCOA +principle. Our factories are approved by a recent FDA inspection.


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Plant Location of Custom Manufacturing

Kinraku Plant:1-2-38 Kinrakuji-cho, Amagasaki-City, Hyogo, 660-0806, Japan
       TEL +81-6-6482-3111 / FAX +81-06-6482-3115
Senboku Plant:1-24 Rinkai-cho, Izumiotsu-City, Osaka, 595-0075, Japan
      TEL +81-725-33-1901 / FAX +81-725-33-1905

Company Information

  • 103-0023 1-12, 4-chome, Nihonbashi honcho, Chuo-ku, Tokyo, JAPAN
  • Tel.+81-3-3231-5580 Fax.+81-3-3231-5583
  • website