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Fujimoto Chemicals Co., Ltd.

Paid-in Capital

87.40 million yen

Number of Employees

203(as of 2020.4.1)


Small scale production / Blending, Subdividing, Filling / Oxidation, Heavy metal compound / No-pressure distillation / Drying, (No-pressure/Vacuum) / Hydrogenation / Bromination / Ullman reaction / Optical microscope / Nuclear magnetic resonance spectrometry(NMR) / Differential scanning calorimetry(DSC) / Liquid chromatography analysis(LC) / Total organic carbon analysis(TOC) / Color difference / Metallic sodium, Metallic potassium / Reduction, Nitro compound / Azidation / Mizoroki-Heck reaction / Kumada-Tamao-Corriu cross coupling / Oxidation, Peroxide / Vacuum distillation / Reduction, Metalic hydride / Low temperature reaction (over -20 C degree) / Photochemical reaction / Chlorination / Nitration / Acylation / Organic lithium / Oganic sulfur compound / Chiral synthesis / Chromatography / Fine Grinding ( <1000μm->=10μm ) / Inductively coupled plasma-atomic emission spectrometry / Scanning electron microscope(SEM) / Electronic microscope / Differential thermal analysis(DTA) / Gas chromatography analysis / Karl Fischer moisture analysis / Specific gravity / Negishi cross coupling / Glaser reaction / Ammoxidation / Reduction, Catalytic / Column purification / Fluorination / Diazotization / Grignard reaction / Optical resolution / Ultrafine Grinding(<10μm) / Inductively coupled plasma-plasma mass spectrometrv(ICP-MS) / Scanning electron microscope(SEM) / Bulk specific gravity / Head Space Gas Chromatography(HS/GC) / Organosilicon compound / Acetalization / Hydrogeneration / Oxidization, Air / Iodination / Acid chlorides / Reaction, NaNH2 / High potency active (HPA) manufacturing / Ultraviolet-Visible spectrophotometer(UV-VIS) / Liquid chromatography analysis-mass spectrometry(LC-MS) / Drying capacity / Thermogravimetric analysis(TG) / Diazo-coupling reaction / Diazocoupling / Sonogashira-Hagihara Cross Coupling / Oxidization, Halogenide / Reaction, NaH / Active sludge process / Suzuki-Miyaura cross coupling / Sandmeyer reaction / Reaction calorimetry / Gas chromatography analysis-mass spectrometry(GC-MS) / Viscosity / Halogenate, Diverse halogenating agents / Amidination / Dehydrogenation / Reduction, High/Middle-pressure / Amination / Sulfonation / Organic sodium / Phosphoric compound / Pollution prevention / Particle size distribution / Halogenate, Thionyl chloride, Sulfuryl chloride etc / Buchwald-Hartwig cross coupling / Oxidation, Swern / Extraction / X-ray diffraction(XRD) / Halogenate, NCS, NBS, NCI etc / Chlorosulfonation / Allylation / Active ingredient for pharmaceutical・cosmetic ingredients / Crystallization / Others, Halogenation / Alkylation / Ion chromatography(IC) / Optical rotation / Sulfonamidation / Chiral compound / Oxidation, Nitric acid / Optical resolution / Aldol reaction / Nitrosation / Coupling reaction / Wittig reaction / Thin layer chromatograph(TLC) / Fusing point / Oxidation, Jones / Reduction, Na/Li / Recrystallization / Esterification / Oppenauer oxidation / Potentiometric titration / Epoxidation / Filtration / Baeyer-Villiger oxidation / Oximation / Carbonylation / Others / Cannizarro reaction / Knoevenagel condensation / Silylation / Diels-Alder / Tishchenko reaction / Perkin reaction / Hydroxyethylation / Hydroxymethylation / Hydroxylation / Vilsmeier reaction / Fries rearrangement / Friedel-Crafts reaction / Hoesch reaction / Hofmann's Reaction / Formylation / Michael addition / Mannich reaction / Methylolation / Racemization / Leuckart reaction / Cyclization / Ring-Opening reaction / Dealkylation / Dehalogenation / Dehydration / Rearrangement / Acid amide / Decarbonation / Quaternarization of Amine, Benzyl oxide /

Manufacture's Feature

Specialize in custom manufacture, research and development and marketing of variety of chemicals. For instance organic functional materials such as API, pharmaceutical intermediates, dye, electronic materials and optical materials, along with food and food additives, raw materials and flagrance for cosmetics and oils.

With half a century worth of synthesis technology and expertise accumulated by our manufacturing division, Fujimoto Chemicals Co., Ltd. achieve satisfactory results in custom research and manufacture of newly-developed products.

Specialized Areas

  • Design Process on each
    development stage
  • Establish "know-how" for
  • Compliant with analysis validation
  • Manufacture as much as user
    need in its development stage
  • From PV manufacture to mass-
    production after a product is
    introduced to the market
  • Agent service for DMF application
    and/or preparation of required
    documentations.(in English)
  • Preparation of required
    documentations for
    domestic/oversea application.
* We provide FA group support for every step
of product development stage.
  • Enhance speed of Pharmaceuticals development

  • All the services are provided under signed confidentiality agreements

  • QA and stable supply guaranteed for custom manufacture service

* Meet your requirement such as;
  1. Sample-level synthesis for early development stage of pharmaceuticals

  2. GLP-compliant sample-level synthesis

  3. Preproduction prototype of the product we developed

  4. GMP-compliant manufacturing line for IND

  5. c-GMP-compliant manufacturing line

Specialized Technologies

* Specialized Technologies

Wealth of experience with synthesis and technology. List of reaction and technology capable in both of our plants are as follows;

  • Acid chloride reaction with thionyl chloride.

  • Side chain chlorination with sulfuryl chloride.

  • Reduction with NaBH4.

  • Heterocycle synthesis with carbon disulphide.

  • Reaction with n-BuLi.

  • Low temperature reaction around -80 C degree.

  • Azidation and tetrazole reaction with NaN3.

  • Separation and purification by column chromatograph with variety of columns.

  • Ultra fine grinding by jet mill.

  • Manufacture category 4-compliant high-potency active ingredients

  • Organic synthesis and reaction of other substances.

* Special compounds actually used in the

carbon disulfide/ hydrazine hydrate/ n-butyllithium/ xydole/ metallic sodium/diisobutylaluminum hydride/ sodium borohydride/ aluminum chloride/ diphenylphosphoryl azide/ organic azide compound/ organic diazo-compound/ Other variety of compounds

* Powder Process
Based on our accumulated expertise on powders, mainly cosmetic raw materials, we provide comprehensive outsourcing service, from a small scale sample production to mass production, of powder process such as surface finishing and treatment.
Mixing, drying, filtration and surface finishing and treatment of powder materials. 
*Inorganic reaction
Nauter mixer, Henschel mixer, kneader
Reactor (Glass, stainless) Dispersion mill (Stainless with homomixer)
Atomizer, Pulverizer, Feather mill
Vibratory siever, ultrasonic sieving apparatus
Electric dryer, tunnel dryer, Reo-Kneader (decompression)
Electric furnace


Based on accumulated technology, we pursue to create high-value added products

In our laboratory, from early stage of development, we research for synthesis channel and formulate marketing strategy compliance with IND GMP regulation. In 2003, IND plant has been built in order to meet customer's requirement and we have an organization and conventional system for smooth technology transfer from lab to plant when products are ready to be introduced to the market.

Custom research/ prototype/ IND manufacturing
IND GMP regulation-compliant manufacturing
Research for manufacturing scale-up/ formulate
Prototype of the product we developed

We have a system to smoothly and seamlessly transfer technology from lab to plant
Search for new synthesis method
Search for synthesis channel by document and
information research

Development of synthesis technology
Define and apply original technology to set trends
for the new era

Specialized Manufacturing Equipment


Our two plants mainly used for manufacturing API, intermediates. Facilities in both plant are listed below. We recently added new facilities and plants as follows. We meet customers requirement by deliver high quality products on time.



GMP Plant

New facilities for manufacturing high-potency active ingredients are introduced in Kiraku Plant on second semester of 2008 and full-scale production line from reaction to isolation has completed. We install the system which control each equipment by its individual optimum control function. The containment measure to deal with category 4 enable us to manufacture anticancer drug.

In 1998 No.3 Senboku Plant
In 2001
Automated rack storage built at Senboku Plant
In 2003
No. 2 Kiraku Plant and IND GMP plant
In 2008
Add new manufacturing facilities for high-potency active ingredients (category 4 products available) at No. 2 Kiraku Plant.

List of facilities

IND GMP Plant( at No.2 Kiraku Plant)

The plant started its operation in January, 2003 is all purpose plant by compartmentalize each sections and installing individual ventilation, with enough space which enable us to expand the facilities in future. Furthermore, new hydrogenation reactor (500L ) was added in 2004.
List of IND GMP-compliant facilities

Qualification for Quality Control

* Various cGMP-compliant SOP available (ICH Q7A API Guideline, The revised Pharmaceutical Affairs Act)
* FDA inspected (1991, 1996, 2000 and 2009)
* API items 15, DMF registered items 7
* nspected by Osaka-fu and Hyogo-ken’s Pharmaceuticals and Chemicals Division for GMP-compliant inspection as well as a broad experience of inspections by multiple domestic/overseas pharmaceutical companies.
* ISO14001 qualified

Plant Location of Custom Manufacturing

Kiraku Plant: 1-2-38 Kirakuji-cho, Amagasaki-shi, Hyogo-ken 660-0806, Japan
Tel: +81-6-6482-3111
  Fax: +81-6-6482-3115
Senboku Plant: 1-24 Rinkai-cho, Izumiootsu-shi, Osaka-fu 595-0075, Japan
Tel: +81-725-33-1901
  Fax: +81-725-33-1905

Company Information

  • 103-0023 1-12, 4-chome, Nihonbashi honcho, Chuo-ku, Tokyo, JAPAN
  • Tel.+81-3-3231-5580 Fax.+81-3-3231-5583
  • website