Chukanbutsu Limited

Paid-in Capital

JPY20000000

Number of Employees

Corporate guidance

Clauson-Kaas/Denmark

Hovione/ Portugal

Dalchem/Russia

HVasant Chemicals/India

Directory

Small scale production / Oxidation, Heavy metal compound / No-pressure distillation / High temperature reaction (over 200 C degree) / Radical polymerization / Drying, (No-pressure/Vacuum) / Granulation / Hydrogenation / Bromination / Ullman reaction / Chemical vapor deposition / Enzymatic reaction / Inorganic compound / Peptide synthesis / Crushing ( >=1mm ) / Peptide synthesis / Synthesis of chemical reagent and pharmaceutical intermediate / Preparative crude refining / Organic elemental analyzer / Nuclear magnetic resonance spectrometry(NMR) / Liquid chromatography analysis（LC） / Color difference / Synthesis of medicinal standard product / Metallic sodium, Metallic potassium / Hydrogen cyanide, Sodium cyanide, Potassium cyanide / Reduction, Nitro compound / Azidation / Mizoroki-Heck reaction / Kumada-Tamao-Corriu cross coupling / Oxidation, Peroxide / Vacuum distillation / Reduction, Metalic hydride / Low temperature reaction (over -20 C degree) / Photochemical reaction / Anionic polymerization / Granulation for agrochemicals / Chlorination / Nitration / Acylation / Organic lithium / Oganic sulfur compound / Chiral synthesis / Chromatography / Fine Grinding ( <1000μm->=10μm ) / Carbohydrate synthesis / Purification, Preparative Isolation / Electronic microscope / Gas chromatography analysis / Specific gravity / Cyanogen chloride / freeze-drying / Cat-CVD / Negishi cross coupling / Dispersion / Rectification / Reduction, Catalytic / High-pressure reaction / Cationic　polymerization / Column purification / Emulsification / High-pressure hydrolysis / Fluorination / Diazotization / Grignard reaction / Optical resolution / Spray drying / Ultrafine Grinding(<10μm) / Glycopeptide synthesis / Hydrogen sulfate / Master batch production/process / Bulk specific gravity / Organosilicon compound / Acetalization / Migita-Kosugi-Stille cross coupling / Reaction, Low boiling point-solvent / Hydrogeneration / Oxidization, Air / Living polymerization / Film distillation / Capsulation / Iodination / Acid chlorides / Acetylenic chemistry / Fermentation / High potency active (HPA) manufacturing / Thin film distillation / Atomic absrptiometric analysis/Flameless atomic absorption spectromety(AAA/FL-AAS) / Liquid chromatography analysis-mass spectrometry(LC-MS) / Drying capacity / Prepared liquid / Diazo-coupling reaction / Dry sterilization / Diazocoupling / Sonogashira-Hagihara Cross Coupling / Polycondensation / Oxidization, Halogenide / Reduction, High-pressure / Steam distillation / Packaging / Fluorine compound / Reaction, NaH / Suzuki-Miyaura cross coupling / Production of small molecule cytotoxics / Gas chromatography analysis-mass spectrometry(GC-MS) / Viscosity / Halogenate, Diverse halogenating agents / Mercaptan / Dehydrogenation / Reduction, High/Middle-pressure / Emulsion polymerization / Sulfonation / Phosgenation / Phosphoric compound / Production of pharmaceuticals/cosmetics / Sublimation / CRO / Particle size distribution / Halogenate, Thionyl chloride, Sulfuryl chloride etc / Amidination / Reduction, Electrolytic / Suspension polymerization / Extraction / Tablet / Amination / Other organometal / Gas absorption / Custom research / Thiophosgene / Combustion heat / Halogenate, NCS, NBS, NCI etc / Chlorosulfonation / Peptide synthesis / Oxidation, Ozone / Re, Electroless / Solution polymerization / Crystallization / Others, Halogenation / Ethylene oxide / Optical rotation / Sulfonamidation / Chiral compound / Allylation / Oxidation, Nitric acid / Reduction, Birch / Reaction with bad smell substances / Optical resolution / Alkylation / Flexibility / Nitrosation / Reaction, Toxic substances / Electrolytic oxidation / Depolymerization / Coupling reaction / Absorption/Ion exchange / Thin layer chromatograph(TLC) / Fusing point / Reduction, Na/Li / Membrance separation / Coagyulation point / Recrystallization / Wittig reaction / Potentiometric titration / Filtration / Etherfication / Metal contents reduction / Esterification / Epoxidation / Others / Others,Oxidation / Oximation / Carbonylation / Guanidination / Kolbe-Schmitt reaction / Silylation / Diels-Alder / Cyanation / Hydroxyethylation / Hydroxymethylation / Hydroxylation / Vilsmeier reaction / Friedel-Crafts reaction / Hofmann's Reaction / Formylation / Methylolation / Racemization / Cyclization / Ring-Opening reaction / Dealkylation / Dehalogenation / Dehydration / Rearrangement / Electrolytic fluorination / Acid amide / Dehydrogenation / Decarbonation / Quaternarization of Amine, Benzyl oxide / Microorganism, Fermentation/Enzymatic /

Application or Material

Manufacture's Feature

Chukan Butsu LTD. is the trading company specialized in export / import of chemicals particularly raw materials for pharmaceuticals and special fine chemicals. Our respective realm of expertise is import and we 本社事務所（7階） either make sole agency agreement and/or tie-up with various manufacturers in the world. Although our partners are not always giants, they are known to provide excellent chemicals such as raw materials for pharmaceutical / pesticide and special fine chemicals. Our wide range of products also includes natural certified color, olive oil and acids used in food additives.
With our major clients located not only in U.S.A. and Western Europe but also in Russia, Eastern Europe countries (Czechoslovakia, Hungary, Poland and Romania), Israel, China and India, we aim to create a sensation and to be known as one and only specialist in the industry.
We are the exclusive agent for Clauson-Kaas/Denmark, Hovione/Portugal, Palindent LTD /Israel, Dalchem/Russia, R.R.Jay/India, Porfa-CIECH/Poland.

Specialized Areas

Clauson-Kaas/Denmark:

Process development of mew molecule
Synthesis of new molecule
Process improvement and modification, cost reduction, response to environmental issues, patent related issues and others
Process development and improvement for mass manufacturing
Production and marketing of existing intermediates

*Production
Small scale production, poly-condensation, hydrogenation, Reaction using low boiling point-solvent, wide variety of oxidation reactions, wide variety of reduction reactions, chiral synthesis and others
*Separation and Refinement
Distillation (at normal pressures level, at depressurized level, steam, molecular and thin film), rectification, chromatography, extraction, chemical resolution, re-crystallization, specific separation, drying, filtration, crystallization and others
*Analysis and Test
For all chemical reactions

Dalchem/Russia:

Organic phosphorous compound
Organic metallic compound
Custom manufacturing

Palindent LTD /Israel:

Production and custom manufacturing of final product and intermediates for pharmaceutical and pesticides
Specialized in nitration, sulfonation, esterification, alkylation and other reactions
Production of fine chemicals such as nitro compound

R.R.Jay/India:

Production and custom manufacturing of final product and intermediates for pharmaceutical and pesticides
Specialized in naphthaline delivertives
Production and custom manufacturing of fine chemicals

Vasant Chemicals/India:

Photo-resist, cationic photo-initiator, composite catalyst and others

Specialized Technologies

Clauson-Kaas/Denmark:

Clauson-Kaas is the independent Denmark research institute established in 1956 specialized in custom manufacturing of organic compounds. Its main business activities consist of laboratory through pilot plant syntheses of new compounds and developing new or modified production processes. They value that this activity consists of developing laboratory procedures which are technically feasible, safe and environmentally acceptable.
The large number of Clauson-Kaas' clients is pharmaceutical manufacturer and its main products are physiologically active substances or intermediates required in the synthesis process to make physiologically active substances that are used in toxicity test and clinical testing.

Dalchem/Russia:

Dalchem is the private company founded in 1997 and although it is relatively small company with around 30 staffs, it specialized in manufacturing organic phosphorous compounds and organic metallic compounds and produce more than 300 kinds of products.
About 80 % of those products are shipped from their stocks, however they are capable of manufacturing other items upon urgent request from customer.
In the area of custom manufacturing, they have expertise on handling air sensitive compounds such as organic phosphorous compounds and organic metallic compounds and pyrophoric compounds and they are available for custom manufacturing with signed nondisclosure agreement.

Palindent LTD /Israel:

Palindent LTD is the member of Israel Chemical LTD family and long established manufacturer of pesticides and pharmaceuticals. Palindent LTD specialized in nitration, esterification, sulfonation and catalytic reduction. Palindent LTD provides the best products to its customers with a help of modern facilities such as state of the art R&D laboratory and pilot plant under strict quality control with workforce consists of skilled hands. Palindent LTD's products are currently used in wide range of applications such as pharmaceutical, pesticide, dye, photographic agent and fabric and it continues to develop new application for its products.

Vasant Chemicals/India:

Vasant, celebrating its 25th anniversary in 2006, is the leading manufacturer of DASDA (4',4'-Diaminostilbene-2',2'-Disulphonic acid) that is main raw material of fluorescent dye. Vasant produces 7,000 ton of DASDA per year and it offers the best quality and price to its customers. Vansant's next target is custom manufacturing market and based on accumulated experience and technology, it fulfills customers various request in 'Specialty Chemicals' custom manufacturing business.

Specialized Manufacturing Equipment

Clauson-Kaas/Denmark:

Pilot plant consists of 3 production lines (180 L GL) and a low-temperature line (capable of cooling to minus 100 C degree / 180 L) with ancillary equipments of necessity such as centrifugal separator, extraction filter and 2 drying rooms.

Dalchem/Russia:

65L stainless steel reactor---10
20L stainless steel reactor---8
22L glass flaek
12L glass flaek
2L autoclave

Palindent LTD /Israel:

Palindent LTD has never stop its facilities innovation, manufacturing process improvement and develop products that has wide range of applications.
With multi-use facilities (compliance to GMP), Palindent' s skilled engineers with a strong product development capability will develop new products to meet customers' requirement. Recently, Palindent LTD has become BSIEN ISO9002 certified company.

Vasant Chemicals/India:

Plant :
Glass Lined Reactors
Stainless Steel Reactors
(capacities ranging from 1 KL to 4 KL)
Heat Exchangers
SS Centrifuges
SS Receivers
Pressure Filter
Milling and Sieving machine

Pilot Plant :
Glass Lined Reactors with Reflux-cum-Distillation
SS 316 Reactors with Reflux-cum-Distillation
SS 316 Reactors
(capacities ranging from 100 -300 ltrs.)
18' SS 316 Centrifuge
Autoclaves
　(capacities ranging from 1 to 10 ltrs.)
All glass set up with Reflux-cum-Distillation
(capacities ranging from 20 - 50 ltrs.)
10 kgs. Vacuum Dryer
25 kgs. Tray Dryer
100 ltrs. SS 316 Blender

Facilities installed in April 2006
0.65 kl & 1 kl SS 316 Reactors
2,6 & 8 sq.mtrs. - SS 316 condensers
160 ltrs. GLR
SS 316 Pressure Nutch Filter
50 ltrs. SS 316 Double Cone Blending Machine
100 ltrs. SS 316 Pressure Reactor
SS 316 Leaf Filter (40 ltrs.)

Qualification for Quality Control

Clauson-Kaas/Denmark:

Everything is compliance to GLP and GMP

Hovione/Portugal:

Accumulated expertise in custom manufacturing approved by FDA and compliance to cGMP.

Dalchem/Russia:

Every batch of products manufactured in Dalchem' s plant goes through quality verification before shipment then shipped with analysis table.
Main analysis method used: NMR (H1, C13, P31), GC, HPLC, polarimeter, C&H Analysis

Palindent LTD /Israel:

With multi-use facilities (compliance to GMP), Palindent' s skilled engineers with a strong product development capability will develop new products to meet customers’ requirement. Recently, Palindent LTD has become BSIEN ISO9002 certified company.

Vasant Chemicals/India:

In ISO 9001 certified system, Vasant prepares a certain file for each customer and all the process including process development, purchase of raw materials, test production, packaging and commercialization of products is controlled based the customer file.

Plant Location of Custom Manufacturing

Clauson-Kaas/Denmark
Hovione/ Portugal
Palindent LTD /Israel
Dalchem/Russia
Vasant Chemicals/India

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