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Nippon Soda Co., Ltd.

Directory

Small scale production / Blending, Subdividing, Filling / Oxidation, Heavy metal compound / No-pressure distillation / High temperature reaction (over 200 C degree) / Radical polymerization / Drying, (No-pressure/Vacuum) / Granulation / Hydrogenation / Bromination / Ullman reaction / Chemical vapor deposition / Inorganic compound / Waste treatment / Crushing ( >=1mm ) / Peptide synthesis / Synthesis of chemical reagent and pharmaceutical intermediate / Collect the ascitic fluid / Cell culture / Husbandry and breeding / Genetic testing of bacteria / Powders (Japanese pharmacopoeia products) / Preparative crude refining / Organic elemental analyzer / Optical microscope / Nuclear magnetic resonance spectrometry(NMR) / Differential scanning calorimetry(DSC) / Liquid chromatography analysis(LC) / Total organic carbon analysis(TOC) / Color difference / Metallic sodium, Metallic potassium / Hydrogen cyanide, Sodium cyanide, Potassium cyanide / Reduction, Nitro compound / Azidation / Mizoroki-Heck reaction / Kumada-Tamao-Corriu cross coupling / Oxidation, Peroxide / Vacuum distillation / Reduction, Metalic hydride / Low temperature reaction (over -20 C degree) / Photochemical reaction / Anionic polymerization / Granulation for agrochemicals / Chlorination / Iodine recovery / Nitration / Acylation / Organic lithium / Oganic sulfur compound / Chiral synthesis / Chromatography / Fine Grinding ( <1000μm->=10μm ) / Purification, Preparative Isolation / Antibody mapping / Microbial culture / Safety test / Dispersion / Disinfectants / Inductively coupled plasma-atomic emission spectrometry / Scanning electron microscope(SEM) / Electronic microscope / Differential thermal analysis(DTA) / Gas chromatography analysis / Karl Fischer moisture analysis / Specific gravity / Cyanogen chloride / Cat-CVD / Negishi cross coupling / Glaser reaction / Rectification / Ammoxidation / Reduction, Catalytic / High-pressure reaction / Cationic polymerization / Column purification / Emulsification / Metal organic CVD / High-pressure hydrolysis / Fluorination / Diazotization / Grignard reaction / Optical resolution / Solvent recovery / Spray drying / Ultrafine Grinding(<10μm) / Measurement of antibody titer / Recombinant microbial culture / Lab animal preparation / Recombinant microbial production / Pharmacology test / Hydrogen sulfate / Ointmennts / Master batch production/process / Inductively coupled plasma-plasma mass spectrometrv(ICP-MS) / Scanning electron microscope(SEM) / Gravimetric analysis(GA) / Specific heat measurement / Bulk specific gravity / Head Space Gas Chromatography(HS/GC) / Organosilicon compound / Acetalization / Migita-Kosugi-Stille cross coupling / Reaction, Low boiling point-solvent / Hydrogeneration / Oxidization, Air / Living polymerization / Film distillation / Iodination / Acid chlorides / Reaction, NaNH2 / Acetylenic chemistry / Electrophoresis migration / Classification / Antibody purification and fragmentation / Detection and identification / Drug stability testing / Carbon disulfide / Alcohol recycling / Drug samples / Thin film distillation / Atomic absrptiometric analysis/Flameless atomic absorption spectromety(AAA/FL-AAS) / Ultraviolet-Visible spectrophotometer(UV-VIS) / Liquid chromatography analysis-mass spectrometry(LC-MS) / Drying capacity / Thermogravimetric analysis(TG) / Prepared liquid / Diazo-coupling reaction / Diazocoupling / Sonogashira-Hagihara Cross Coupling / Polycondensation / Oxidization, Halogenide / Reduction, High-pressure / Steam distillation / Packaging / Fluorine compound / Reaction, NaH / Active sludge process / Suzuki-Miyaura cross coupling / Bioscience / Test on cell / Gene expression (Protein production) / Biofilm fouling test / Sandmeyer reaction / Pelletization / X-ray fluorescence analysis(XRF) / X-ray photoelectron spectroscopy(XPS) / Atomic force microscope(AFM) / Infrared spectroscopy(IR) / Reaction calorimetry / Gas chromatography analysis-mass spectrometry(GC-MS) / Viscosity / Synthesis of pesticide metabolite / Halogenate, Diverse halogenating agents / Mercaptan / Reaction, Special medium(liquid ammonia etc) / Dehydrogenation / Reduction, High/Middle-pressure / Emulsion polymerization / Molecular distillation / Flaker / Sulfonation / Organic sodium / Phosgenation / Phosphoric compound / Production of pharmaceuticals/cosmetics / Pollution prevention / Sublimation / Collection and management of strain and cell / Vaporization calorimetry / Particle size distribution / Halogenate, Thionyl chloride, Sulfuryl chloride etc / Amidination / Buchwald-Hartwig cross coupling / Oxidation, Swern / Reduction, Electrolytic / Suspension polymerization / Extraction / Tablet / Amination / Other organometal / Consultation, Waste / Gas absorption / Thiophosgene / X-ray diffraction(XRD) / Thermal expansion coefficient measurement / Pyrolysis gas chromatography(PGC) / Combustion heat / Halogenate, NCS, NBS, NCI etc / Chlorosulfonation / Peptide synthesis / Oxidation, Ozone / Re, Electroless / Solution polymerization / Crystallization / Others, Halogenation / Ethylene oxide / Thermal conductivity measurement / Ion chromatography(IC) / Optical rotation / Sulfonamidation / Chiral compound / Allylation / Oxidation, Nitric acid / Reduction, Birch / Reaction with bad smell substances / Solid Phase polymerization / Optical resolution / Alkylation / Flexibility / Gel permation chromatography(GPC) / Nitrosation / Reaction, Toxic substances / Electrolytic oxidation / Depolymerization / Coupling reaction / Wolff-Kishner-reduction / Absorption/Ion exchange / Aldol reaction / Thin layer chromatograph(TLC) / Fusing point / Oxidation, Jones / Reduction, Na/Li / Membrance separation / Coagyulation point / Recrystallization / Wittig reaction / Oppenauer oxidation / Potentiometric titration / Filtration / Etherfication / Baeyer-Villiger oxidation / Metal contents reduction / Esterification / Epoxidation / Hyroxylation, Microorganism enzyme / Oximation / Carbonylation / Cannizarro reaction / Guanidination / Knoevenagel condensation / Kolbe-Schmitt reaction / Silylation / Schiemann reaction / Strecker reaction / Diels-Alder / Tishchenko reaction / Cyanation / Perkin reaction / Hydroxyethylation / Hydroxymethylation / Hydroxylation / Vilsmeier reaction / Fries rearrangement / Friedel-Crafts reaction / Hoesch reaction / Hofmann's Reaction / Formylation / Michael addition / Mannich reaction / Methylolation / Racemization / Leuckart reaction / Cyclization / Ring-Opening reaction / Dealkylation / Dehalogenation / Dehydration / Rearrangement / Acid amide / Dehydrogenation / Decarbonation / Quaternarization of Amine, Benzyl oxide / Microorganism, Fermentation/Enzymatic /

Application or Material

Manufacture's Feature

Since our founding in 1920, Nippon Soda has accu-mulated unique technologies and know-how, and provided highly functional and high value added chemical products in such diverse fields as specialty chemicals, agrochemicals and pharmaceuticals. We can manufacture samples or products from early de-velopment stage to commercial stage.
We respond to your various requests utilizing the experiences of various commercial productions.
We provide high quality products to customers with high manufacturing technology and reliable product analytical technology.

Raw materials having a feature
Phosgene, Thiophosgene, Oxalyl chloride,
Hydrogen Cyanide, Cyanogen chloride,
DAMN (Diaminomaleonitrile)
TosMIC (Toluenesulfonylmethyl isocyanide),
Sulfur compounds, Carbon disulfide,
Metal sodium, Butyl lithium,

Special technologies
Reaction using phosgene,
Reaction using cyanogen compound including produc-tion of DAMN
Handling reaction of odorous compounds of sulfur,
Lithiation reaction (formylation, carboxylation and boron acids synthesis),
Palladium coupling reaction (Mizoroki Heck reaction, Suzuki Miyaura reaction and Sonogashira Hagiwara re-action),
Ruthenium hydrogenation reaction,
Asymmetric Synthesis (Asymmetric hydrogenation, Asymmetric alkylation, Asymmetric cyanation),
Reaction using alkali metals (Sodium,lithium)

We are waiting for a contact from customers.

Specialized Areas

Nippon Soda is one of the few companies that can handle Phosgene, Thiophosgene carbonyl and Hy-drogen cyanide in custom manufacturing in Japan.

(1)Reactions of Phosgene

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(2)Reactions of Thiophosgene

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(3)Reactions of Oxalyl chloride

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(4)Reactions of Hydrogen Cyanide

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(5)Reactions of DAMN (Diaminomaleonitrile)

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(6)Reactions of TosMIC (Tosylmethyl isocyanide)

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(7)Sulfur compounds

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(8)Living Anionic Polymerization Technique
The world's first commercial polymerization by living anionic polymerization

a. NISSO-PB (1,2-Polybutadiene)
* NISSO-PB is a liquid atactic butadiene oligomer which is obtained and polymerized by living anionic polymerization. We have manufactured 1,2-polybutadiene resins, their hydrogenated resins, their modified resins, etc. using this method.

[Characteristics]
* Customized average molecular weights of 1000, 2000 and 3000.
* About 85% of oligomer frameworks are 1,2-vinyl bond structures.

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b. VP-Polymer (Poly p-hydroxy styrene)
* VP-polymer is poly p-hydroxyl styrene manufactured by living anionic polymerization.

[Characteristics]
* High reproducibility of molecular weight and clear-ness.
* Low dispersivity.

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Specialized Technologies

* We can manufacture from early development stage to commercial stage. (Laboratory samples, pilot-scale samples, commercial products)
* We respond to your various requests utilizing the experiences of various commercial productions while we discuss and offer you propose you most efficient manufacturing process.
* We make effective use of our possessed characteristic raw materials (Phosgene, Thiophosgene, hydrogen cyanide, DAMN, TosMIC and sulfur compounds), and manufacture several chemicals utilizing our synthetic technology.
* We provide high quality products to customers with high manufacturing technology and reliable product analytical technology.
* We have incinerators and activated sludge treatment facilities so we can disposal several industrial waste chemicals including odorous materials.

New Product & Developed Product

1) Lithiation reaction
a. Formylation and Carboxylation

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b. Boronic acid synthesis

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2) Palladium Coupling Reaction
a. Mizoroki Heck reaction

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b. Suzuki-Miyaura Reaction

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c. Sonogashira-Hagiwara Cross Coupling Reaction

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3) Reactions using molecular catalysts
a. Asymmetric hydrogenations

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Other Synthesis Examples

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b. Asymmetric alkylations

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c. Asymmetric cyanations

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Qualification for Quality Control

* ISO9001, ISO14001 and OHSAS18001 are acquired by whole factory.
* Responsible Care (RC) activity is being promoted aggressively.

Plant Location of Custom Manufacturing

Nihongi Plant
950, Fujisawa, Nakago-ku, Joetsu, Niigata
949-2392, JAPAN
Takaoka Plant
300, Mukainohonmachi, Takaoka, Toyama
933-8507, JAPAN
Mizushima Plant
2767-12, Kojima shionasu, Kurashiki, Okayama
711-0934, JAPAN
Chiba Plant
12-8, Goiminamikaigan, Ichihara, Chiba
290-8530, JAPAN
Additionally cooperation company

Other Features

key word

contracted manufacture, fine chemicals, speciality chemicals, agricultural chemicals and medicinal chemicals,phosgene, isocyanetes, sulfonyl isocyanates, acid chlorides, chloroformates, isocyanides, aldehydes, carbonates, imidoyl chlorides, NCAs and α-chloropyridines, thiophosgene, chlorothioformates, thiocarbonates,
alkenes, oxalyl chloride, oxalyl chloride mono-alkyl ester, hydrogen cyanide, DAMN, pyrazines, dicyanopyrazines, piperazines, imidazoles, purines, cyanogen chloride, cyanates, chlorosulfonyl isocyanate, nitriles, cyanohydrines, sodium cyanide, isothiocyanates, sodium thiocyanates, TosMIC, oxazoles, pyrroles, FAMSO, carbon disulfide,
sodium sulfite, thiocarboxylic acid, thiourea, thiol compound, thiocarbonyl compound, sulfur-containing hetero ring compound, organolithium, LDA, carboxylic acids, boronic acids, Grignard reagents, metallic sodium, sodium alkoxides, magnesium alkoxides, titanium alkoxides, zirconium alkoxides,
phosphorus trochloride, phosphorus oxychloride, optical activitie butanediol, Optical activities ephedrine, optical active quinuclidinol, chlorination, cyanation, phosgenation, formylation, carboxylation, lithiation, acid chlorination, imidoylation, carbonate esterification, hydrogenation, alkylation, cyclization,
palladium catalyzed reaction, palladium coupling reaction, Mizoroki Heck reaction, Suzuki Miyaura reaction, Sonogashira Hagiwara reaction, asymmetric synthesis, high enantioselective catalytic reaction, asymmetric hydrogenation, asymmetric alkylation, asymmetric cyanation,

Company Information

  • 100-8165 Shin-ohtemachi Bldg., 2-1, Ohtemachi-2-Chome, Chiyoda-Ku, Tokyo, Japan
  • Tel.+81-3-6327-5468 Fax.
  • website